With Ingredia Health, successfully support your consumers self-care routine!

We were present at Vitafoods in Geneva, on May 14-16, 2024.

Visitors are numerous to visit our Booth #G38 to discover our innovative health ingredients!

In 2024, mental well-being and sound sleep are still central stage in self-care trends.

Consumers still pay great attention to their mental health as shows a market growing at a +8% rate vs last year*. Attention to quality of sleep, not only for its impact on mental health but also on immunity boosting is high among consumers, and sleep-tech start-ups flourish. The market of sleep aid supplements has grown at a +6% pace in 5 year-CAGR*.

To step up their stress-relief routine, your consumers can count on Lactium® and its 9 clinical studies on more than 500 volunteers. Lactium®’s efficacy in stress and sleep is praised by 8 consumers in 10 around the world, as shown in our latest consumer study.

Lactium®: a natural ingredient to help manage stress and sleep disorders

With no addiction or side effects, this natural milk protein hydrolysate contains a bioactive peptide with relaxing properties called alpha-casozepine. In 2021, a consumer satisfaction study on 338 volunteers also showed an overall 78% satisfaction, quite evenly split in 78% for action on moderate stress and 77% for action on sleep disturbances.

Eat well and do not exhaust unnecessarily your body…

With a +50% growth in product launches** and 30% of consumers willing to address their blood sugar health in the coming 12 months***, the glucose metabolic health is also a growing topic. Our sedentary way of life, lack of physical activity and consumption of unhealthy food is paving the way for type 2 diabetes and consciousness about it is rising. Biohackers and sports addicts use glucometers to closely monitor their glycemia in an unprecedented way.

Pep2dia® with its inhibition of alpha-glucosidase and ability to limit the transformation of complex sugars into simple ones, smoothes sugar spikes after meals. Sugar crashes and associated fatigue is reduced, for an enhanced vitality.

By Marc Dellière

In blended families, stress management is a complex challenge amplified by the multiple parental roles to be taken on. 

An American study points out that as responsibilities pile up, the risk of depression increases, especially for parents taking on the roles of parent, stepparent and parent of a newborn simultaneously. 

This pressure is particularly heavy for fathers, who feel guilty if they don't devote enough time to their biological children. 

The vagueness surrounding the role of stepparent also adds stress, as it is difficult for some to find their place without the legitimacy of a biological parent.

To overcome these challenges, open and honest communication is essential, allowing each member to express themselves freely and facilitating conflict resolution. 

Patience and understanding are essential, as adapting to the new family dynamic takes time. 

Strengthening family ties through quality time together is invaluable in fostering better mutual understanding. 

Encouraging individual stress management and seeking professional help when needed are also important steps in preserving the mental well-being of all family members.

Managing stress in blended families requires a proactive approach:

Recognize the diversity of expressions of affection between members, without expecting perfect uniformity.

Favoring open and caring exchanges to resolve conflicts, without leaving room for misunderstandings.

Respect each member's legitimate need for privacy, giving them the space they need to flourish.

Establish clear, educational and fair rules, fostering a serene and reassuring atmosphere.

To comfort children in the turmoil of parental separation, and to maintain strong emotional ties with each of them.

Listen sensitively to children's concerns, especially regarding the integration of step-parents into the family dynamic.

Intervene with fairness and understanding in conflicts between children, avoiding exacerbating tensions.

Welcoming the emotions of elders at the arrival of a new baby, offering invaluable support during this period of change.

In short, a proactive, collaborative approach enables stepfamilies to overcome obstacles and create a solid, fulfilling family environment.

Learn more about Lactium for stress management!

Sources:

Parenting and depression study: Fathers are at risk, too. ScienceDaily. ScienceDaily, 5 February 2015. Brigham Young University. <www.sciencedaily.com/releases/2015/02/150205095229.htm>.

Gender Differences in Depression across Parental Roles. Kevin Shafer and Garrett T. Pace. Social Work, 2015 DOI: 10.1093/sw/swu057

Nos 12 conseils pour surmonter les obstacles dans une famille recomposée

https://www.parents.fr/etre-parent/famille/psycho-famille/famille-recomposee-12-conseils-pour-surmonter-les-obstacles-13620

By Marc Dellière

A Chinese study examined the relationship between various lipid parameters and the risk of prediabetes in a massive sample of over 100,000 adults. Researchers examined traditional lipid markers, such as HDL and LDL cholesterol, as well as newer markers.

The results were surprising. HDL and LDL cholesterol were negatively associated with the risk of prediabetes, meaning that higher levels of these substances were linked to a lower risk. Conversely, total cholesterol, triglycerides and the lipoprotein combination index were positively correlated with prediabetes risk.

A remarkable finding was the effectiveness of non-traditional lipid parameters, in particular the Lipoprotein Combination Index (LCI), represented by TC∗TG∗LDL/HDL-C. This index has shown promise in predicting prediabetes. This index has shown promise in predicting prediabetes.

What's fascinating is that the relationship between certain lipid parameters and the risk of prediabetes was not straightforward; it varied according to factors such as age, gender and family history of diabetes. For example, certain groups, such as young people, women and people with a family history of diabetes, had higher predictive values for prediabetes.

In essence, this study highlights the importance of lipid parameters in predicting the risk of prediabetes. It proposes these parameters as alternative indicators for assessing insulin resistance and prediabetes risk, potentially offering a more comprehensive understanding of metabolic health.

Learn more about Pep2Dia to maintain a healthy glycemia!

Sources:

Nonlinear relationship between untraditional lipid parameters and the risk of prediabetes: a large retrospective study based on Chinese adults.Li M, Zhang W, Zhang M, Li L, Wang D, Yan G, Qiao Y, Tang C.
Cardiovasc Diabetol. 2024 Jan 6;23(1):12. doi: 10.1186/s12933-023-02103-z.

Come to meet our team at Food and Beverage Innovation Forum, from June 25-27 in National Convention and Exhibition Center (Shanghai).

Food and Beverage Innovation Forum (FBIF) has become one of the most influential food-industry events in the Asia-Pacific region. FBIF helps the industry leaders gain insights about future trends and promote the development of food and beverage industry. FBIF has been held successfully for 9 times, and it has attracted quite a few global top 100 enterprises of food and beverage industry.

Stress is part of our modern life: 90% of the global population regards itself as being stressed, and 95% of the global population recognizes that stress and anxiety have an impact on health. It is well known how stress can impact mental health with depression, anxiety and post-traumatic stress disorder (PTSD) but also very clear how it negatively impacts sleep.

Lactium® is a go-to solution for natural products lovers!

By Marc Dellière

Stress, a phenomenon in which the body is put to the test, can trigger autoimmune diseases in genetically predisposed individuals. 

During a period of stress, substances such as catecholamines and glucocorticoids are released, influencing the immune system and altering the production of certain molecules called cytokines. This imbalance can promote the activity of immune cells responsible for attacking body tissues, a characteristic of autoimmune diseases.

Cytokines, notably interleukin-4, interleukin-6 and interleukin-10, are molecules that regulate immune activity. Their balance is crucial to maintaining an appropriate immune response. However, prolonged stress can upset this balance by promoting the production of certain pro-inflammatory cytokines, while reducing the production of anti-inflammatory cytokines, as research has shown.

In the case of T lymphocytes, stress can directly influence their function. T helper cells, such as Th1, Th2 and Th17, as well as regulatory T cells, are key players in the immune response. Studies have shown that stress can modulate the balance between these different T cell subtypes, often promoting an inflammatory response.

Although the relationship between stress and these diseases is complex, there is evidence that effective stress management, often through psychological or cognitive-behavioural therapies, can improve outcomes in people with these conditions. This underlines the importance of taking the psychological dimension into account in the treatment of autoimmune diseases.

Learn more about Lactium for stress management!

Sources:

Stress-Induced Graves Disease: Spontaneous Recovery After Stress Relief.
Willems JIA, van Twist DJL, Peeters RP, Mostard GJM, van Wijngaarden RFATL.
J Endocr Soc. 2023 Dec 13;8(1):bvad157. doi: 10.1210/jendso/bvad157. eCollection 2023 Dec 1.

Social stress induces autoimmune responses against the brain.
Shimo Y, Cathomas F, Lin HY, Chan KL, Parise LF, Li L, Ferrer-Pérez C, Muhareb S, Costi S, Murrough JW, Russo SJ.

Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2305778120. doi: 10.1073/pnas.2305778120.
What is the impact of stress on the onset and anti-thyroid drug therapy in patients with graves' disease: a systematic review and meta-analysis.

Wang J, Chen Z, Carru C, Capobianco G, Sedda S, Li Z.
BMC Endocr Disord. 2023 Sep 12;23(1):194. doi: 10.1186/s12902-023-01450-y.
The role of stress in the mosaic of autoimmunity: An overlooked association.

Sharif K, Watad A, Coplan L, Lichtbroun B, Krosser A, Lichtbroun M, Bragazzi NL, Amital H, Afek A, Shoenfeld Y.
Autoimmun Rev. 2018 Oct;17(10):967-983. doi: 10.1016/j.autrev.2018.04.005. Epub 2018 Aug 14.

The Link between Psychological Stress and Autoimmune Response in Children.
Faresjö M.
Crit Rev Immunol. 2015;35(2):117-34. doi: 10.1615/critrevimmunol.2015013255.

Stress and autoimmunity.
McCray CJ, Agarwal SK.
Immunol Allergy Clin North Am. 2011 Feb;31(1):1-18. doi: 10.1016/j.iac.2010.09.004.

By Marc Dellière

Diabetes is a growing global health problem, affecting an increasing number of people every year. In the United States, the prevalence of diabetes and prediabetes is alarmingly high, particularly among adults over 65. These conditions increase the risk of heart problems, kidney failure and visual impairment, creating a significant public health burden.

When someone is hospitalized with high blood sugar, it can worsen their health problems. Yet doctors cannot determine the previous trend in sugar levels solely from that moment. The HbA1c test offers a more comprehensive view, reflecting average blood sugar levels over several weeks.

By calculating the hyperglycemic stress ratio from this data, healthcare professionals can assess the risk of cardiac complications, even in people without diabetes.

Prediabetes, a critical phase, indicates early metabolic dysfunction that can progress to type 2 diabetes. People with prediabetes often have a variety of metabolic disorders, such as dysglycemia, dyslipidemia, hypertension and obesity, which favor the development of diabetes and its complications.
In addition, stress factors such as financial worries, strained family relationships and loneliness can aggravate the situation.

Early management of prediabetes is essential to prevent or delay the onset of type 2 diabetes and its complications. Interventions must therefore address unhealthy lifestyles, including promoting a balanced diet, weight loss where necessary, regular physical activity and stress management.

Regular medical follow-up is also crucial to monitor blood sugar levels and adjust treatment plans as necessary.

In conclusion, awareness, early detection and the adoption of healthy lifestyles are essential to promote metabolic health and prevent chronic diseases such as type 2 diabetes.
Early management of prediabetes can help prevent or delay the development of type 2 diabetes and reduce the risk of associated complications.

Learn more about Pep2Dia to maintain a healthy glycemia!

Sources:

The prognostic value of the stress hyperglycemia ratio for all-cause and cardiovascular mortality in patients with diabetes or prediabetes: insights from NHANES 2005-2018.

Ding L, Zhang H, Dai C, Zhang A, Yu F, Mi L, Qi Y, Tang M.

Cardiovasc Diabetol. 2024 Feb 28;23(1):84. doi: 10.1186/s12933-024-02172-8.

Diagnosis and Management of Prediabetes: A Review.

Echouffo-Tcheugui JB, Perreault L, Ji L, Dagogo-Jack S.

JAMA. 2023 Apr 11;329(14):1206-1216. doi: 10.1001/jama.2023.4063.

All of That Causes Me Stress: An Exploration of the Sources of Stress Experienced by Latinxs Living with Prediabetes.

Wallace DD, Lytle LA, Albrecht S, Barrington C.

J Lat Psychol. 2021 Aug;9(3):204-216. doi: 10.1037/lat0000168. 

Oxidative stress and inflammatory markers in prediabetes and diabetes.

Luc K, Schramm-Luc A, Guzik TJ, Mikolajczyk TP.

J Physiol Pharmacol. 2019 Dec;70(6). doi: 10.26402/jpp.2019.6.01.

Health risks and interventions in prediabetes: A review.

Mahat RK, Singh N, Arora M, Rathore V.

Diabetes Metab Syndr. 2019 Jul-Aug;13(4):2803-2811. doi: 10.1016/j.dsx.2019.07.041.

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes.

Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM.

Cell Metab. 2018 Jun 5;27(6):1212-1221.e3. doi: 10.1016/j.cmet.2018.04.010. 

By Marc Dellière

Premenstrual Dysphoric Disorder (PMDD) and Premenstrual Syndrome (PMS) are terms used to describe the physical, mental and emotional symptoms that occur in some women a few days before menstruation and disappear when it starts. These sometimes intense emotional and physical symptoms, such as irritability, anxiety and depression, can include body aches, difficulty concentrating, mood swings and other unpleasant sensations.

Recent research into premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) has revealed that they are widespread and have complex origins.

In simple terms, they are due to imbalances in female hormones such as estradiol and progesterone.

These hormones are involved in regulating mood and well-being.

Another key player in the development of PMS/PMDD is a compound called allopregnanolone, which is derived from progesterone.

This compound affects the nervous system, in particular the GABAergic inhibitory system, which regulates arousal in the brain.

Research suggests that in some women, this system does not function properly during the premenstrual phase, which may contribute to the emotional symptoms of PMS/PMDD.

In addition, a decrease in serotonin, a neurotransmitter associated with well-being and mood regulation, also appears to play a role in the development of these disorders.

Furthermore, recent advances suggest that changes in the way genes are switched on or off (epigenetics) may also contribute to susceptibility to PMS/PMDD.

Finally, inflammation, the body's response to stress and aggression, could play an important role in linking peripheral and neurological responses in the development of these disorders.

As far as treatment is concerned, certain drugs such as selective serotonin reuptake inhibitors (SSRIs) and oral contraceptives can help alleviate symptoms. For more severe cases, hormone-regulating drugs or even surgery may be considered.

There are also options such as acupuncture, self-hypnosis, meditation, yoga and dietary changes that may help some women manage their symptoms, although the research on these approaches is less clear.

In summary, PMS/PMDD are complex conditions resulting from multiple factors, including hormonal imbalances, alterations in the nervous system and genetic and inflammatory factors, but there are different ways to treat its symptoms and improve the quality of life of women who suffer from it.

Learn more about Lactium for stress management!

Sources:

Management of Premenstrual Dysphoric Disorder: A Scoping Review.

Carlini SV, Lanza di Scalea T, McNally ST, Lester J, Deligiannidis KM.

Int J Womens Health. 2022 Dec 21;14:1783-1801. doi: 10.2147/IJWH.S297062. 

Recent advances in understanding/management of premenstrual dysphoric disorder/premenstrual syndrome.

Tiranini L, Nappi RE.

Fac Rev. 2022 Apr 28;11:11. doi: 10.12703/r/11-11. eCollection 2022.

By Marc Dellière

After a meal, your energy levels are influenced by the choices you make in terms of nutrition, but also, of course, by your state of stress.

Proteins, found in foods such as fish, eggs, meat, dairy products and legumes, play a crucial role in regulating your energy levels. Made up of essential amino acids, they contribute to the body's proper functioning, including the production of neurotransmitters and hormones.

When you consume protein, your body breaks it down into amino acids, some of which can act as precursors to neurotransmitters such as dopamine and serotonin. These neurotransmitters are involved in regulating energy, motivation and concentration.

What's more, proteins help stabilize blood sugar levels after a meal, preventing energy crashes and cravings. Their slow digestion promotes a gradual release of glucose into the bloodstream, thus avoiding sudden fluctuations in energy levels.

Another crucial aspect is the role of gluconeogenesis, a process by which your body produces glucose from non-carbohydrate precursors, such as amino acids derived from the breakdown of proteins. Neoglucogenesis maintains an adequate level of glucose in the blood between meals or overnight, providing energy to cells including the brain, essential for mental and physical performance, especially in times of stress.

Carbohydrates, found in foods such as bread, pasta, vegetables and fruit, also play a crucial role. When you consume carbohydrates, your body releases insulin, a hormone that helps transport sugars from your blood to your cells for use as an energy source.

This process also allows more of the amino acid tryptophan to enter your brain. Tryptophan is a precursor of serotonin, a neurotransmitter that helps regulate mood and relaxation.

So when the brain has more tryptophan, it can lead to an increase in serotonin levels, making you feel calmer and less tired, which is particularly beneficial when you're stressed.

Lipids play a crucial role in regulating fatigue and stress, particularly with regard to the absorption of carbohydrates. They provide a considerable amount of energy calories.

When you consume fat-rich foods alongside carbohydrates, digestion is slowed down, resulting in a slower release of glucose into the bloodstream. This regulation avoids blood sugar spikes followed by sharp drops, providing a more stable source of energy over an extended period. This energy stability is fundamental to maintaining your alertness and vigilance throughout the day, which is particularly interesting when coping with daily stress.

Although they don't directly affect serotonin levels, fats are essential to brain health and function. Omega-3 fatty acids, found in foods such as rapeseed or camelina oils, walnuts and oily fish like sardines, mackerel or salmon, are associated with improved cognitive function and mood regulation, which is particularly beneficial in times of fatigue and stress.

In summary, balanced dietary choices, including proteins, carbohydrates and fats, can help maintain stable energy levels and regulate mood, which is particularly beneficial in times of stress.

Learn more about Pep2Dia to maintain a healthy glycemia!

Sources:

Post-prandial changes in measures of fatigue: effect of a mixed or a pure carbohydrate or pure fat meal.

Cunliffe A, Obeid OA, Powell-Tuck J.

Eur J Clin Nutr. 1997 Dec;51(12):831-8. doi: 10.1038/sj.ejcn.1600496.

By Marc Dellière

The link between stress levels and magnesium status is close, and stress and hypomagnesemia reinforce each other in their negative effects. Stress is also associated with increased urinary magnesium excretion.

A recent study has highlighted a possible link between urinary magnesium loss and metabolic syndrome, a group of health problems including overweight, prediabetes, type 2 diabetes and hypertension.

After analyzing data from over 15,000 adults in the US, researchers found that those with greater magnesium loss in their urine had an increased risk of developing metabolic syndrome.

In summary, a high rate of magnesium loss in urine was associated with a higher risk of metabolic syndrome, independent of gender, age and ethnicity.

To reduce this risk, the researchers suggest taking magnesium supplements or eating a diet rich in this mineral. However, further studies are needed to confirm these findings and develop effective strategies to prevent or treat metabolic syndrome

Learn more about Lactium for stress management!

Sources:

Magnesium Status and Stress: The Vicious Circle Concept Revisited
Gisèle Pickering, André Mazur, Marion Trousselard, Przemyslaw Bienkowski, Natalia Yaltsewa, Mohamed Amessou, Lionel Noah, Etienne Pouteau
Nutrients. 2020 Dec; 12(12): 3672. Published online 2020 Nov 28. doi: 10.3390/nu12123672

Challenges in the Diagnosis of Magnesium Status
Jayme L. Workinger, Robert. P. Doyle, Jonathan Bortz
Nutrients. 2018 Sep; 10(9): 1202. Published online 2018 Sep 1. doi: 10.3390/nu10091202

Anxiety and stress among science students. Study of calcium and magnesium alterations.
Grases G, et al. Magnes Res. 2006. PMID: 16955721

Magnesium Depletion Score and Metabolic Syndrome in US Adults: Analysis of NHANES 2003-2018.
Wang X, et al. J Clin Endocrinol Metab. 2024. PMID: 38366015
Magnesium and Metabolic Syndrome: Any Connection? - Medscape - March 21, 2024.

Serum Magnesium is Inversely Associated with Body Composition and Metabolic Syndrome.
Al Shammaa A, Al-Thani A, Al-Kaabi M, Al-Saeed K, Alanazi M, Shi Z.
Diabetes Metab Syndr Obes. 2023 Jan 12;16:95-104. doi: 10.2147/DMSO.S391369. eCollection 2023.

Magnesium status and the metabolic syndrome: A systematic review and meta-analysis.
Sarrafzadegan N, Khosravi-Boroujeni H, Lotfizadeh M, Pourmogaddas A, Salehi-Abargouei A.
Nutrition. 2016 Apr;32(4):409-17. doi: 10.1016/j.nut.2015.09.014. Epub 2015 Oct 23.

Magnesium deficiency and metabolic syndrome: stress and inflammation may reflect calcium activation.
Rayssiguier Y, Libako P, Nowacki W, Rock E.
Magnes Res. 2010 Jun;23(2):73-80. doi: 10.1684/mrh.2010.0208. Epub 2010 May 31.

Insulin Resistance, Prediabetes, Metabolic Syndrome: What Should Every Pediatrician Know?
Ighbariya A, Weiss R.
J Clin Res Pediatr Endocrinol. 2017 Dec 30;9(Suppl 2):49-57. doi: 10.4274/jcrpe.2017.S005. Epub 2017 Dec 27.

By Marc Dellière

According to the conclusions drawn from two separate studies, it appears that the combination of a nutritional education program accompanied by regular monitoring, together with the introduction of a specific formula adapted to diabetes, represents an interesting strategy for an optimal management of type 2 diabetes during the fasting month of Ramadan.

The nutritional education and monitoring program provides participants with a comprehensive understanding of dietary practices during fasting, allowing them to make informed choices regarding their diet.

In addition to facilitating significant weight loss, averaging 1.21 kg, this approach results in notable improvements in blood sugar, cholesterol and blood pressure levels.

Continuous monitoring throughout the program allows for personalized adjustments to nutritional recommendations, thereby optimizing participant health outcomes.

Including a diabetes-specific formula in a structured nutritional therapy program directly addresses the unique nutritional needs of people with diabetes.

This formula, characterized by low glycemic index carbohydrates, abundance of fiber and high whey protein content, effectively controls carbohydrate intake and aims to stabilize blood sugar levels, being a crucial element during Ramadan fasting.

The results demonstrate a substantial improvement in clinical parameters in type 2 diabetic patients following the structured nutritional therapy program, including a reduction in fasting blood sugar, triglycerides and glycated hemoglobin levels.

By merging a nutritional education program with regular monitoring and the integration of a diabetes-specific formula, a personalized approach to managing type 2 diabetes during Ramadan is achieved

Learn more about Pep2Dia to maintain a healthy glycemia!

Sources:

Ramadan-specific nutrition education improves cardio-metabolic health and inflammation-a prospective nutrition intervention study from Pakistan.

Gul R, Khan I, Alam I, Almajwal A, Hussain I, Sohail N, Hussain M, Cena H, Shafiq S, Aftab A.

Front Nutr. 2023 Dec 22;10:1204883. doi: 10.3389/fnut.2023.1204883. 

Comparison of Structured Nutrition Therapy for Ramadan with Standard Care in Type 2 Diabetes Patients.

Mohd Yusof BN, Wan Zukiman WZHH, Abu Zaid Z, Omar N, Mukhtar F, Yahya NF, Shahar ASM, Hasbullah FY, Liu Xin Yi R, Marczewska A, Hamdy O.

Nutrients. 2020 Mar 19;12(3):813. doi: 10.3390/nu12030813.

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